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In their first year of college, two young women, one from a Florida swamp, the other from a Kentucky holler, both outsiders at their prestigious east coast college, meet in "Introduction to Sketch" and become instant best friends. A decade later, Mel and Sharon's lives remain intertwined, but so much else has changed. Now a semi-famous New York filmmaking duo, they draw upon their own pasts to make intimate animated movies, a process that has left their personal lives--including their friendship--in tatters. When tragedy strikes, Mel and Sharon must return to their home states to confront long-buried secrets and try to restore damaged relationships with their families, lovers, and each other" --